Jinan University/Biomedical engineering
Tissue Engineering, Stem Cells, Biomaterials, CNS Repair/Regeneration, Wound Healing
Neural stem/progenitor cell 3-D differentiation for repair of central nervous system injuries
Chitosan is a natural biomaterial (distributed widely in insects, invertebrates, fungi and yeasts) that mimics native polysaccharides such as hyaluronan, and has many useful biological properties such as bioresorbable degradation products, hydrophilicity, biocompatibility, and cellular binding capabilities that make chitosan well suited as a tissue engineering scaffolding material. I have selected chitosan as the basic substrate to support neural stem cell 3-D differentiation and proliferation; both in vitro and in vivo. The main objective was to develop a preferred method to encourage neural stem/progenitor cell (NSPC) differentiation into desired cell types (neurons, oligodendrocytes and astrocytes). All studies focused on testing how different 3-D biomaterial-growth factor systems guide NSPC differentiation, in order to form tissue engineered constructs. This knowledge is invaluable for future treatments targeted for regenerating the injured or damaged center nervous system.